Lizzie Borden and her sister are living as outcasts in Fall River, Massachusetts after the brutal murders of their father and step-mother. Though Lizzie is the main suspect, she goes free after a lengthy trial. Rumor and suspicion follow her but Lizzie has bigger things to worry about. Namely, a sinister illness that is slowly staking its claim on the inhabitants of Fall River, turning them into hideous creatures intent on spreading their infection and madness.